BTK PROTAC 10 ( —— )

Catalog No. M16951 CAS No.

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

BTK PROTAC 10
Note

Research use only, not for human use.
Brief Description

BTK PROTAC 10 is a novel potent PROTAC for BTK with DC50 of 1.1 nM in cultured Ramos cells.
Description

BTK PROTAC 10 is a novel potent PROTAC for BTK with DC50 of 1.1 nM in cultured Ramos cells; can successfully delivered to tissues and can specifically degrade BTK in vivo, in a dose-dependent and tissue-biased manner by s.c. administration.
Synonyms

——
Pathway

PROTACs
Target

PROTAC
Recptor

PROTAC
Research Area

——
Indication

——

CAS Number

--
Formula Weight

976.99
Molecular Formula

C47H54F2N8O13
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(N1C[C@H](N2N=C(C3=CC=C(OC4=CC=C(F)C=C4F)C=C3)C(C(N)=O)=C2N)CCC1)OCCOCCOCCOCCOCCOCCNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O
Chemical Name

17-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1Hisoindol-4-yl]amino}-3,6,9,12,15-pentaoxaheptadec-1-yl(3R)-3-{5-amino-4-carbamoyl-3-[4-(2,4-difluorophenoxy)phenyl]-1H-pyrazol-1-yl}piperidine-1-carboxylate

1. Zorba A, et al. Proc Natl Acad Sci U S A. 2018 Jul 16. pii: 201803662.

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